An overwhelming majority of the global population, approximately 95%, have suffered from a headache at some point in their lives, with an alarming annual prevalence that suggests nearly half of all adults have experienced a headache within a given year. Migraine and associated symptoms are a significant burden to the financial, mental, and physical wellbeing of those that live with this chronic disease. Migraine it is a common chronic disorder it is typically characterized by attacks of headache and accompanying symptoms including aura. The understanding of migraine pathophysiology has evolved over the years. There are several different theories surrounding migraine development and maintenance. The aetiology is multifactorial with rare monogenic variants depression, epilepsy, stroke, migraine attacks themselves act as stressor. This review provides an overview that both stress and migraine are reciprocally related cyclically influencing each other across time. The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current deficiencies that exist in the efficacy and adherence rate of approved anti-migraine medications.
Migraine, etiology, epidemiology, headache
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